Rosuvastatin Effect on Telomere-telomerase System in ACS
Status:
Unknown status
Trial end date:
2016-11-01
Target enrollment:
Participant gender:
Summary
Coronary heart disease (CHD) is one of the diseases characterised by biological aging as one
of the important risk factors in several epidemiological studies. The mean telomere length
and telomerase activity serve as markers for the biological age at the cellular level, with
shorter telomeres and lower telomerase activity defining the increased biological age.
Telomere length and telomerase activity, therefore, correlates with the risk of CHD and
atherosclerosis. A present study states that the treatment with a statin is associated with a
reduction in the number of clinical events but only in individuals with increased risk based
on their telomere length. This suggests a positive relationship of telomere and telomerase
system with the treatment with statins in CHD patients.