RosaC-RF : Bipolar Radiofrequency vs Doxycycline in Rosacea
Status:
Unknown status
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Rosacea is a chronic facial disfiguring dermatosis characterized by different stages like
flushing, erythema, telangiectasia and papulo-pustular lesions. Recommended treatments
include topical (metronidazole) and systemic (doxycycline) antibiotics with only a suspensive
effect. The bipolar radiofrequency (RF) with Elos system (infrared light) is a device
emitting an electromagnetic current inducing an increase in temperature when applied on the
skin, potentiated by infrared light. The monopolar RF has already been used in rosacea on a
small number of cases with positive and prolonged results. RF with Elos system has been
evaluated on erythemato-telangiectasic rosacea with encouraging results. Demodex folliculorum
(DF) is a long transparent mite which asymptomatically parasitizes pilosebaceous follicle of
normal human skin sometimes responsible of inflammatory facial dermatoses. The prevalence and
density of DF are increased in rosacea, and DF is suspected to play a role in the
pathogenesis of rosacea. DF is sensitive to heat, and the investigators hypothesize that
radiofrequency treatment may affect the survival of the mite and should be effective to treat
papulopustular rosacea.