Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
Smoking has a negative effect on the predictability and stability of root coverage procedures
because of decreased blood supply and fibroblast activity. Long-term evaluation of this
procedure in smokers is important for clinical decision making, because it provides
information about the stability of results over time. In smokers, enamel matrix derivative
(EMD) used at acellular dermal matrix graft (ADMG)/ soft tissue interface could be an
alternative to improve the deficient healing potential, since EMD has the capability of
stimulating angiogenesis. At the ADMG/ root surface interface, it could improve the deficient
fibroblast activity in smokers and therefore reduce the presence of a long junctional
epithelium. The aim of this randomised controlled clinical study was to investigate whether
EMD contributes to the root coverage of gingival recessions performed with ADMG in smokers
during a 12-month follow-up.
Twenty smokers with bilateral Miller Class I or II gingival recessions ≥ 3 mm will be
selected. The test group will be treated with an association of ADMG and EMD, and the control
group with ADMG alone. Some clinical parameters as: probing depth, relative clinical
attachment level, gingival recession height, gingival recession width, keratinized tissue
width and keratinized tissue thickness will be evaluated before surgery and after twelve
months.