Role of Volatile Anesthetics for Hepatic Protection

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Zurich
• Treatments: Anesthetics; Sevoflurane

Criteria

Inclusion Criteria:

• Older than 18 years of age

• Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria:

• Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)

• Liver cirrhosis