Overview

Role of Vitamin D and Its Topical Analogues in Pathogenesis and Treatment of Acne Vulgaris

Status:
Unknown status

Trial end date:
2021-03-01

Target enrollment:
0

Participant gender:
All

Summary

Acne vulgaris is a chronic skin disease of the pilosebaceous unit characterized by formation of papules, pustules, comedones, nodules and cysts. It can have a major psychological burden on the patients. It develops due to blockage of the hair follicles. This is thought to occur as a result of the following four abnormal processes: a higher than normal amount of sebum production, excessive deposition of keratin leading to comedo formation, hair follicles' colonization by Propionibacterium acnes (P. acnes) and the local release of pro-inflammatory mediators. Androgens also play a role in pathogenesis either from elevated levels or exacerbated response

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Assiut University

Treatments:

Adapalene
Ergocalciferols
Vitamin D
Vitamins

Criteria

Inclusion Criteria:

1. Patients with Acne of any grade.

2. Patients between 18 and 45 years old.

Exclusion Criteria:

1. Patients below 18 and above 45years.

2. Patients with any concomitant Dermatologic or systemic illness

3. Patients on any topical or systemic medication within 4 weeks before enrollment.

4. Pregnancy.