Role of SNP and DIGOXIN Response in Atrial Fibrillation Patients

• Status: Completed
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study tested the hypothesis that response to digoxin is modulated by single Nucleotid Polymorphism (SNP):

• Multi Drug Resistance (MDR1) gene haplotypes and Solute carrier organic anion transporter family member 1B3 (SLCO1B3) gene Polymorphism and their role in the response to treatement.

• Aldosterone synthase (CYP11B2) gene and sodium channel, voltage-gated, type V alpha subunit gene (SCN5A) correlated with atrial fibrillation and their roles in response to digoxin.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Monastir
• Treatments: Digoxin

Criteria

Inclusion Criteria:

• Patients older than 20 years

• Quick AF (heart rate> 120 bpm) diagnosed by ECG

Exclusion Criteria:

• HR under 120 bpm

• Hemodynamically unstable patients

• Atrio-Ventricular-block (second or third degree)

• Ventricular rhythm disorder

• Acute coronary syndrome

• kidney failure

• Hypokalimia