Overview

Role of Liquid Phase Concentrated Growth Factors vs. Hypertonic Dextrose Prolotherapy for Management of Patients With Disc Displacement Without Reduction

Status:
Not yet recruiting
Trial end date:
2021-06-01
Target enrollment:
0
Participant gender:
All
Summary
Purpose of the study is to compare clinically, radiographically and biochemically the effect of intra- articular injection of hypertonic dextrose with a stabilization appliance and the intra- articular injection of 2 ml of liquid phase concentrated growth factor with a stabilization appliance as a prolotherapy for temporomandibular joint anterior disc displacement without reduction.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Nourhan M.Aly
Collaborator:
Alexandria University
Treatments:
Mitogens
Criteria
Inclusion Criteria:

- Patients with painful TMJ.

- Patients with limited mouth opening (MMO <40mm).

- Patients with anterior disc displacement without reduction confirmed by MRI.

- Presence of full or nearly full complement of natural teeth.

- Patients with angle class I occlusion.

- Patients with RCP not greater than 2mm and with no open bite.

Exclusion Criteria:

- Patients who have anterior disc dislocation with reduction detected by MRI.

- Inability or unwillingness to undergo magnetic resonance imaging (MRI) such as
implanted electronic devices.

- Patients having uncontrolled systemic disease, hematologic or neurologic disorders or
inflammatory diseases.

- Patients under anticoagulant drug therapy.