The purpose of this research study is to learn new information about the underlying cause of
aspirin-exacerbated respiratory disease (AERD) and the benefit of high-dose aspirin therapy.
AERD is a disease that involves asthma, recurring nasal polyps, and respiratory reactions to
aspirin and other nonsteroidal anti-inflammatory drugs. This study will be conducted on
individuals with AERD who are referred to the Brigham and Women's Hospital AERD Center for
clinical evaluation and potential aspirin desensitization. Desensitization to aspirin and
subsequent treatment with daily high-dose oral aspirin is standard of care for patients with
AERD who do not respond adequately to steroids and have recurrent nasal polyposis or
symptomatic asthma. This study will involve five visits to Brigham and Women's Hospital and
will align closely with the standard of care for the treatment of AERD.