Role of Infected Blood Dendritic Cells in Heart Disease Risk

• Status: Completed
• Trial end date: 2014-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators hypothesize that blood dendritic cells harbor pathogens from the oral cavity in chronic periodontitis and disseminate these pathogens to atherosclerotic plaques.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Augusta University
• Collaborator: National Institute of Dental and Craniofacial Research (NIDCR)
• Treatments: Amoxicillin; Anti-Bacterial Agents; Antibiotics, Antitubercular; Chlorhexidine gluconate; Dexlansoprazole; Lansoprazole

Criteria

Inclusion Criteria:

• generalized moderate to severe chronic periodontitis

Exclusion Criteria:

• diabetes

• antibiotics treatment within 3 months

• treatment with steroids, phenytoin, cyclosporin, coumadin

• presence of conditions requiring prophylactic antibiotics per AHA

• cancer, HIV, hepB, lupus, prediagnosed heart disease, renal disease

• smoker