Role of Hypertonic Saline Versus Mannitol in the Management of Raised Intracranial Pressure in Patients With ALF
Status:
Completed
Trial end date:
2015-11-01
Target enrollment:
Participant gender:
Summary
Patients with ALF (Acute liver Failure) would undergo a detailed clinical evaluation.
Information would be collected regarding the onset and duration of symptoms, etiology, and
severity of disease, other baseline clinical features, demographic characteristics, routine
biochemical and hematological investigations. Patients would also be screened for the
assessment of raised intracranial hypertension by either clinical or neuroimaging or by ONSD
(optic nerve sheath diameter) and TCD (Transcranial doppler ultrasonography). Patient found
to be having risen ICP (Intra Cranial Pressure) would be randomized in the two groups of the
study. The group A would receive intravenous mannitol 20 to 30 minutes every 4 hourly where
as those in the group B would be given 3% hypertonic saline as continuous infusion at a rate
of 25ml /hr and titrated q4 hrs per sliding scale to achieve a target serum sodium level of
144-155 mmol/L .Both the groups would receive other supportive measures such as head end
elevation, oxygen supplementation, dextrose infusion to maintain normoglycemia standard
medical treatment.