Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection
Status:
Unknown status
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
In the presented project, the role of heme oxygenase 1 and 2 in the procesess associated with
fibroproduction in the chronic HCV infection will be studied. Heme oxygenase expression will
be evaluated by the techniques of molecular genetics and immunohistochemistry, both in the
liver tissue and in peripheral blood mononuclear cells. These parameters will be correlated
with basic virological and clinical characteristics of the chronic HCV infection. The
investigators' expected results may help in understanding the mechanisms of fibroproduction
in chronic HVC infection and, therefore, contribute to explain individual differences in the
development of chronic HCV infection.