Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity

• Status: Not yet recruiting
• Trial end date: 2024-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

The aim of this project is to determine role for ET-1 in individuals with obesity.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia

Criteria

Inclusion Criteria:

• 18-55 years of age

• Male sex

• Obese (BMI ≥30 kg/m2)

Exclusion Criteria:

• Female sex

• Current smoking/Nicotine use

• Nerve/neurologic disease

• Cardiovascular, hepatic, renal, respiratory disease

• Blood pressure ≥140/90 mmHg

• Diabetes

• Vigorous exercise >3 times/week

• Communication barriers

• taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic