Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Status:
Not yet recruiting
Trial end date:
2029-12-31
Target enrollment:
Participant gender:
Summary
The goal of this clinical trial is to examine the role of autophagy on microvascular function
in adults with Type 2 Diabetes. The main question it aims to answer are:
- Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function?
- Does exposure to high glucose impair autophagy and subsequently microvascular function?
Participants will undergo 2 study days. The primary outcome will be in vivo microvascular
function testing. Following the first study day participants will undergo either
supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second
study day will test in vivo microvascular function.