Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
Status:
NOT_YET_RECRUITING
Trial end date:
2026-12-01
Target enrollment:
Participant gender:
Summary
Glucagon secretion from -cells has long been viewed as primarily a counterregulatory mechanism - e.g. an agent with a role to prevent blood sugar from decreasing to levels that compromise function. Our group, along with other researchers, have begun to identify a much more complex role for -cells, raising questions about when and how glucagon may influence blood glucose levels. This proposal looks to detail proglucagon peptide secretion from -cells and the impact this has on -cell function and glucose tolerance, in preclinical studies of human islets and translational studies in human subjects.
This protocol registration describes Aim 2 from this NIH grant which involves 2 study populations and separate protocols but addresses a common question. Aim 3 in the grant is focused on a separate hypothesis and will be conducted and published separately from Aim 2.
Phase:
PHASE4
Details
Lead Sponsor:
David D'Alessio, M.D.
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)