Role of Allopurinol on Oxidative Stress and Mitochondrial Alterations in Skeletal Muscle of Diabetic Patients
Status:
Completed
Trial end date:
2016-02-18
Target enrollment:
Participant gender:
Summary
Our recent data in mice have demonstrated a key role of xanthine oxidase in
hyperglycemia-induced by Reactive oxygen species production, and a preventive role of
allopurinol (inhibitor of xanthine oxidase) on the keeping of mitochondria number and
structure, in skeletal muscle of diabetic mice. The investigators want to initiate a clinical
trial in order to evaluate the efficacy of allopurinol on the improvement of mitochondrial
alterations, oxidative capacities and insulin sensitivity, in skeletal muscle of type 2
diabetic patients.