Overview

Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease

Status:
Recruiting
Trial end date:
2023-12-01
Target enrollment:
0
Participant gender:
All
Summary
This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsules(BIFICO) on motor symptoms and constipation and sleep in mild to moderate Parkinson's disease and the safety of the study; 2. the mechanism of the improvement effect of intestinal microecological changes on motor and constipation symptoms in mild to moderate Parkinson's disease.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Beijing Friendship Hospital
Criteria
Inclusion Criteria:

- Age 40-80 years old, both male and female;

- Patients with primary Parkinson's disease who meet the 2015 MDS clinical diagnostic
criteria; PD with modified Hoehn-Yahr stage 1-3 and MDS-UPDRS II+III score ≥ 14 and no
significant off periods or off periods ≤ 1.5 hours per day (excluding morning motor
inability);

- Pre-enrollment therapeutic medications included Levodopa and Benserazide Hydrochloride
Tablets, and all Parkinson's disease medications were unadjusted and motor symptoms
were stable for 28 days prior to enrollment;

- No probiotic or/and prebiotic (including lactulose) and antibiotic therapy for 60 days
prior to enrollment, and if so, a 60-day washout period;

- Understand and agree to follow the study protocol, agree to be enrolled and sign the
informed consent form.

Exclusion Criteria:

- Parkinson's superimposed syndrome and secondary Parkinson's syndrome, such as multiple
system atrophy, progressive supranuclear palsy, etc.;

- Taking any probiotic or prebiotic (including lactulose) within 60 days prior to
enrollment; having inflammation at any site and using any antibiotic within 60 days
prior to enrollment; or having blood leukocytes above the upper limit of normal at
screening;

- Combined endocrine disorders, such as history of diabetes or fasting glucose ≥ 7.8
mmol/L, hyper- or hypothyroidism, adrenal tumors, abnormal pituitary function, etc.;

- Comorbid other neurological disorders, such as cognitive impairment, Mini-Mental State
Examination(MMSE) scale score <24; severe anxiety states and/or severe depressive
states (Hamilton Depression Inventory-17 item score >17, Hamilton Anxiety Scale score
≥14, or being treated with antidepressant anxiety medication); malignancy, spinal cord
lesions, epilepsy, autonomic disorders (urinary retention, urinary incontinence, or
upright hypotension , blood pressure drop ≥30/15 mmHg at any time point within 5
minutes of uprightness), etc.; new cerebrovascular disease or sequelae of severe
cerebrovascular disease within 6 months, which affects the assessment;

- Gastrointestinal tumors, history of inflammatory bowel disease, other acute and
chronic inflammation of the gastrointestinal tract (including acute attacks of
cholecystitis) within 3 months;

- History of gastrointestinal surgery (excluding endoscopic resection of
gastrointestinal benign polyps, appendicitis resection) or constipation caused by
surgery;

- History of anal fissure, perianal abscess, irreversible anal prolapse, pelvic trauma;

- Severe cardiovascular disease (such as congestive heart failure with a heart function
classification of Ⅲ-Ⅳ by the American Heart Association, a history of myocardial
infarction within 6 months, etc.);

- Severe liver and kidney dysfunction with glutamate-pyruvate transaminase, aspartate
transaminase and total bilirubin 1.5 times higher than the upper limit of normal;
serum creatinine 1.5 times higher than the upper limit of normal;

- Pregnant and lactating women or women of childbearing age (40-60 years) who are human
chorionic gonadotropin (HCG)-positive;

- Known allergy to test drugs or related products;

- People with a history of drug abuse or alcohol dependence;

- Those who have participated in other clinical trials within 3 months prior to
enrollment;

- Refusal to enroll and inability to cooperate with the investigator; patients judged by
the investigator to be unsuitable for enrollment.