Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium

• Status: Completed
• Trial end date: 2020-05-01
• Target enrollment: 0
• Participant gender: All

Summary

180 patients will be randomly divided into two groups 90 patients each using a computer-generated program.

Group R: 90 patients will receive a Rivastigmine patch (4.6 mg) 24 h before the operation to 3 days post-operative Group M: 90 patients will receive Melatonin patch (7 mg) 24 h before the operation to 3 days post-operative Patients in the two groups will be compared regarding incidence and severity of delirium on postoperative days 1, 2 or 3 and 7

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Melatonin; Rivastigmine

Criteria

Inclusion Criteria:

• American Society of Anaesthesiologists physical status I-III,

• Aged 60-85 years old,

• Undergoing major orthopaedic surgery

Exclusion Criteria:

• History of CNS disorders, such as brain injury, stroke; mental illness; dementia

• Metabolic disorders and electrolyte disturbances

• Alcohol or drug dependence

• Secondary surgery or severe infectious complications

• Severe sensory impairment causing difficulty in communication (deafness or blindness)

• Medications affecting CNS as (Antipsychotics, Anticonvulsants, Antiparkinsonian, Antidepressants)