Acute Rheumatic Fever is an autoimmune inflammatory post-infectious syndrome, mainly caused
by type A streptococcus. It is characterized as an inadequate immune response. It may provoke
carditis, combined with articular, skin and neurologic signs. Only carditis, prevalent in 60%
of acute rheumatic diseases, may provoke valvular sequels, which define rheumatic
cardiopathy. Antibiotherapy based on penicillin is the standard treatment of both acute
rheumatic fever and its prevention. Although no anti-inflammatory treatment has proved its
efficacy, with or without steroids anti-inflammatory treatments are administered in acute
episode of ARF. Up to date, only prevention strategies have shown efficacy.
Phase:
Phase 2
Details
Lead Sponsor:
Paris Cardiovascular Research Center (Inserm U970)