Risperidone Maintenance Treatment in Schizophrenia
Status:
Completed
Trial end date:
2004-12-01
Target enrollment:
Participant gender:
Summary
This study set out to determine the duration of maintenance treatment with therapeutic
risperidone dose in schizophrenia. In a multi-center, open label, randomized, controlled
study design, patients with schizophrenia who were clinically stabilized following an acute
episode were randomly assigned to a 'maintenance group' (optimal therapeutic doses continued
for at least 1 year), a 4-week group (optimal therapeutic doses continued for 4 weeks
followed by a 50% dose reduction that was maintained for at least 11 months) or a 26-week
group (optimal therapeutic doses continued for 26 weeks followed by a 50% dose reduction for
at least another 6 months).