Risperidone-Induced Hyperprolactinemia Treated With Bromocriptine

• Status: Unknown status
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

Antipsychotic drugs can cause a clinically relevant hyperprolactinemia due to blocking the dopamine receptors in the pituitary.Schizophrenic patients suffering from a neuroleptic-induced hyperprolactinemia will be examined endocrinologically. Adverse drug effects and diagnoses will be confirmed by measuring hormones.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Bonn
• Treatments: Bromocriptine; Risperidone

Criteria

Inclusion Criteria:

• Female and male schizophrenic patients.

• Antipsychotic treatment with risperidone.

• Diagnosis of a clinically relevant hyperprolactinemia.

• No indication of disturbance of the somato-, cortico or thyreotropic hypophysis-axis (IGF-1, cortisol, ACTH, TSH, FT3, FT4)

Exclusion Criteria:

• Severe somatic disease, especially coronary disease.

• Acute psychotic exacerbation.

• Pregnancy