Risk of Uncomplicated Peptic Ulcer in the General Population
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
The analyses are conducted in a previous population-based cohort study using The Health
Improvement Network database in the UK (Cai et al 2009).The aims of the post hoc analyses
are:
To estimate the relative risk of uncomplicated symptomatic peptic ulcer (UPU) associated with
use of low dose aspirin (ASA) and other anti-inflammatory drugs (NSAIDs, steroids) in the
general population To estimate the dose-response and duration-response associated with use of
these drugs To estimate the relative risk of UPU associated with naive/non-naive use of low
dose ASA in the general population To evaluate the effect of proton pump inhibitors (PPI)
(alone or in combination with anti-inflammatory drugs) on the occurrence of UPU in the
general population To investigate the management of low dose ASA/oral antiplatelets after UPU