Overview

Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved?

Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
0
Participant gender:
All
Summary
Vitamin K2 deficiency has been shown to be profound in hemodialysis patients. It is reflected by high plasma levels of dephosphorylated-undercarboxylated Matrix Gla protein (dp-ucMGP) and seems to be correlated with vascular calcifications. Vascular calcifications can be assessed using the AC24 score on a lateral abdominal X-ray. The aim of this study is to assess first the rate of decrease of dp-ucMGP in a hemodialysis cohort after supplementation with vitamin K2 and the correlation between this rate of decrease and the Aortic Calcification Severity (AC24) score. The factors associated with high levels of dp-ucMGP will be analyzed as well.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Saint-Joseph University
Treatments:
Vitamin K
Vitamin K 2
Vitamin MK 7
Vitamins
Criteria
Inclusion Criteria:

- Patients on chronic hemodialysis in our center older than 18 years old who sign the
informed consent.

Exclusion Criteria:

- Patients who are not eligible for a discontinuation of vitamin k antagonists