Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma
Status:
Not yet recruiting
Trial end date:
2032-06-01
Target enrollment:
Participant gender:
Summary
This study builds on the results of several prior studies that we have been involved with to
test the hypothesis that Risk-Adapted De-Intensification of Radiation Therapy and
chemotherapy based on HPV subtype, plasma circulating free HPV DNA (cfHPV DNA) level, and
cfHPV DNA clearance rate produces Local-Regional Control rates that are similar to what has
been achieved with more aggressive therapy in patients with Favorable Prognosis Oropharyngeal
Squamous Cell Carcinoma (OPSCC).