Right Ventricular Hemodynamics Using Cardiac MRI in Patients COPD and OSA

• Status: Completed
• Trial end date: 2020-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patient has been termed overlap syndrome, affecting 1% of the U.S. population.The investigators propose to conduct this study that aims: (1) to compare right and left ventricular hemodynamic parameters using cardiac magnetic resonance imaging (MRI) in overlap syndrome vs. COPD only and OSA only; (2) to compare the effects of bi-level positive airway pressure (BPAP) vs. nocturnal oxygen therapy (NOT) on right ventricular (RV) hemodynamics in overlap syndrome.

This study will allow us to test the hypothesis: (1) Patients with overlap syndrome have more RV dysfunction than those with COPD only or OSA only; (2) treatment of both hypoxemia and hypercapnia during sleep will improve RV hemodynamics compared with treatment of hypoxemia alone in patients with overlap syndrome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of California, San Diego

Criteria

Inclusion Criteria:

• Both men and women with age more than 18 years.

• Known diagnosis of stable COPD (GOLD stage 2 or higher) or OSA.

Exclusion Criteria:

• Already using continuous positive airway pressure (CPAP), BPAP device, or nocturnal oxygen.

• Known or suspected renal failure with estimated Glomerular filtration (GFR) <50 ml/min/1.73 m2 or serum creatinine > 1.5 mg/dl.

• Chronic atrial fibrillation or frequent premature ventricular contraction (> 10 beats per hour)

• Women known to be pregnant or planning to be pregnant in next 6 months.

• Known contraindication to MRI: cardiac pacemaker, metallic heart valves, metallic implants, history of claustrophobia.

• If taking sildenafil or related drugs, unable to stop it within 48 hours of the study visit.

• Uncontrolled COPD or acute COPD exacerbation.

• Unstable cardiac diseases.

• Known chronic inflammatory diseases like lupus or active infection.