Overview

Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty

Status:
Unknown status

Trial end date:
2014-12-01

Target enrollment:

Participant gender:

Summary

The number of patients requiring joint replacement is increasing due to its success in restoring function and pain relief, and the growing population of the elderly. One of the most serious complications of arthroplasty is joint prosthesis infection. Due to the absence of prospective, randomized, controlled studies, there is no consensus concerning diagnosis and treatment of prosthetic joint infections. The main objective of this trial is to evaluate the clinical efficacy of rifampin combination therapy versus monotherapy using cloxacillin or vancomycin in early staphylococcal infections after total hip and knee arthroplasty.

Phase:

Phase 4

Details

Lead Sponsor:

Oslo University Hospital

Treatments:

Anti-Bacterial Agents
Anti-Infective Agents
Cloxacillin
Rifampin
Vancomycin