Overview

Ricolinostat, Gemcitabine Hydrochloride, and Cisplatin in Treating Patients With Unresectable or Metastatic Cholangiocarcinoma

Status:
Withdrawn
Trial end date:
2021-10-01
Target enrollment:
0
Participant gender:
All
Summary
This phase Ib trial studies the side effects and best dose of ricolinostat when given together with gemcitabine hydrochloride and cisplatin in treating patients with cholangiocarcinoma that cannot be removed by surgery or has spread to other places in the body. Ricolinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as gemcitabine hydrochloride and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving ricolinostat together with gemcitabine hydrochloride and cisplatin may work better in treating patients with cholangiocarcinoma that cannot be removed by surgery or has spread to other places.
Phase:
Phase 1
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Collaborator:
National Cancer Institute (NCI)
Treatments:
Cisplatin
Gemcitabine
Ricolinostat
Succinylcholine
Criteria
Inclusion Criteria:

- Histological or cytologic confirmation of unresectable or metastatic
cholangiocarcinoma (intrahepatic, hilar, extrahepatic bile duct)

- Measurable disease

- Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2

- Absolute neutrophil count (ANC) >= 1200/mm^3

- Platelet count >= 100,000/mm^3

- Total bilirubin < 1.5 x upper limit of normal (ULN), If patient has known Gilbert's
syndrome, direct bilirubin < 2.0 x ULN

- Aspartate transaminase (AST) =< 5 x ULN

- Alkaline phosphatase =< 5 x ULN

- Creatinine =< 1.5 x ULN

- Negative pregnancy test done =< 7 days prior to registration, for women of
childbearing potential only

- Ability to complete a patient medication diary by themselves or with assistance

- Provide informed written consent

- Willingness to return to enrolling institution for follow-up (during the active
monitoring phase of the study)

- Willingness to provide tissue and blood samples for correlative research purposes

- Life expectancy >= 3 months

- Prior embolization, chemoembolization, or radiofrequency ablation permitted if >= 4
weeks from registration and evidence of new tumor growth is present

Exclusion Criteria:

- Any of the following

- Pregnant women

- Nursing women

- Men or women of childbearing potential who are unwilling to employ adequate
contraception

- Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment
of the investigator, would make the patient inappropriate for entry into this study or
interfere significantly with the proper assessment of safety and toxicity of the
prescribed regimens

- Immunocompromised patients and patients known to be human immunodeficiency virus (HIV)
positive and currently receiving antiretroviral therapy; NOTE: patients known to be
HIV positive, but without clinical evidence of an immunocompromised state, are
eligible for this trial

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Central nervous system (CNS) metastasis; NOTE: history of brain metastasis other than
locally treatable lesions (i.e., lesions treatable with surgery or radiosurgery);
patients with locally treatable disease may be considered for study if they have
completed treatment without evidence of CNS progression for > 4 weeks after completion
of treatment; patients with a history of brain or other CNS metastases not amenable to
local therapy will not be eligible

- Prior biologic or immunologic therapy =< 4 weeks prior to study entry

- Prior systemic chemotherapy for cholangiocarcinoma or gallbladder carcinoma; NOTE:
adjuvant chemotherapy is allowed if completed > 6 months prior to the start of
registration

- Prior radiation of cholangiocarcinoma or gallbladder carcinoma; NOTE: adjuvant
radiation therapy is allowed if completed > 6 months prior to the start of
registration

- Receiving any other investigational agent which would be considered as a treatment for
the primary neoplasm

- Other active malignancy =< 5 years prior to registration; EXCEPTIONS: non-melanotic
skin cancer or carcinoma-in-situ of the cervix or breast, or prostatic intraepithelial
neoplasm; NOTE: if there is a history or prior malignancy, patient must not be
receiving other specific treatment (other than hormonal therapy) for their cancer

- History of myocardial infarction =< 6 months from registration, or congestive heart
failure requiring use of ongoing maintenance therapy for life threatening ventricular
arrhythmias