Rho Kinase (ROCK) Inhibition in Carotid Atherosclerosis

• Status: Terminated
• Trial end date: 2011-01-20
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the causal relationship between Rho/Rho kinase overactivity and mechanisms of vascular dysfunction in patients with atherosclerosis.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Brigham and Women's Hospital
• Collaborator: Doris Duke Charitable Foundation
• Treatments: Fasudil

Criteria

Inclusion Criteria:

• Subjects with >= 70% carotid stenosis (unilateral or bilateral) who are scheduled to undergo elective carotid endarterectomy

• Age >= 18 years

• Agreement of the operating surgeon for patient to participate

Exclusion Criteria:

• Surgery scheduled < 14 days after randomization

• Pregnancy

• ALT, GGT > 3x upper limit of normal (ULN)

• Creatinine > 3.5 mg/dL

• Prior intolerance to statins

• Reluctance to add or change dosage of statin therapy during study