Rhabdomyosarcoma and Malignant Soft Tissue Tumours of Childhood
Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Objective of the study objectives was to explore survival advantage for an intensified
chemotherapy strategy in a randomised trial.
IVA (ifosfamide, vincristine, actinomycin D) or a 6 drug combination (IVA + carboplatin,
epirubicin, etoposide) both delivered over 27 weeks. Cumulative dose / m2 = ifosfamide 54g
(both arms), epirubicin 450 mg, etoposide 1350 mg (6 drug). Delivery of radiotherapy was
determined according to site and / or response to chemotherapy ± surgery.
The study was powered to detect 10% difference in 3 year OS.