Reversal of Dual Antiplatelet Therapy With Cold Stored Platelets
Status:
Active, not recruiting
Trial end date:
2021-12-03
Target enrollment:
Participant gender:
Summary
This study aims to determine whether cold-stored platelets (CSP) are equally, more effective,
or uniquely effective at reversing the effect of dual antiplatelet therapy in healthy human
subjects compared to room-temperature-stored platelets (RTP). The investigators plan to
enroll healthy human subjects without risk factors for bleeding to achieve 60 complete data
sets. Each subject will donate two apheresis platelet units. One platelet unit will be stored
in the cold (CSP) and one platelet unit will be stored at room temperature (RTP). Subjects
will be given dual anti-platelet therapy (aspirin and clopidogrel) prior to autologous
transfusion of each unit. Platelet function testing will be performed before and after
transfusion to measure reversal of the antiplatelet drugs.