Reversal of Complete Heart Block With Aminophylline in Inferior Wall Myocardial Infarction Patients

• Status: Not yet recruiting
• Trial end date: 2023-06-18
• Target enrollment: 0
• Participant gender: All

Summary

In this study we will evaluate the rate of reversal of complete heart block with aminophylline in atropine resistant patients with inferior wall myocardial infarction (MI)

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Cardiovascular Diseases, Karachi
• Treatments: Aminophylline; Theophylline

Criteria

Inclusion Criteria:

• Adult patients admitted with recent acute inferior wall myocardial infarction (MI)

• Hemodynamically stable blood pressure

• Complete heart block with Narrow QRS < 120 ms and ventricular rate >40/min persisting for at least 6 hours resistant to atropine

• Temporary pacemaker (TPM) already placed

• Patient asymptomatic with mean arterial pressure of greater than 65 mmHg with TPM rate placed at 40/min

Exclusion Criteria:

• Patients with cardiogenic shock

• Patients with preexisting permanent pacemaker and Implantable Cardioverter Defibrillator (ICD).

• Patients with prior history of AV block

• Drugs with dromo-tropic effects (beta blocker, calcium channel blocker, inotropes)

• Known liver disease (cirrhosis, hepatitis)

• Hypothyroidism

• Unable to consent