This feasibility study will allow for the determination of the in vivo recovery and time of
dialysis to optimize a future thorough microdialysis study. This is a single session, open
label study to evaluate the feasibility of microdialysis for Retapamulin in healthy subjects.
Three healthy subjects will be enrolled and complete the study procedures. Subjects will be
admitted to the research unit on Day 1 and three microdialysis probes will be placed in the
thigh of each subject prior to the start of the microdialysis procedure. After normal saline
solution infusion for 30 minutes, a Retapamulin solution will be infused for 90 minutes.
Saline perfusion will occur during the washout period. Microdialysis sampling will be done
for 30 minutes (during the last 30 minutes of drug perfusion) and dialysate sample collection
will continue every 30 minutes for 4 hours. The approximate duration of study including
follow-up is 4 days.