The main objective of this study is to investigate the effect of resveratrol on inflammatory
mediators and insulin resistance at the cellular and molecular level in obese non diabetic
and type 2 diabetic subjects in vivo. This research will investigate the hypothesis that
resveratrol, when given orally to obese and type 2 diabetic subjects induces a decrease in
reactive oxygen species (ROS) generation and the pro-inflammatory transcription factor
nuclear factor-kB (NF-kB) and the inflammatory mediators regulated by it. The hypothesis that
resveratrol suppresses the high fat, high carbohydrate (HFHC) meal induced inflammatory and
oxidative response, will also be investigated. This research will also investigate the
hypothesis that resveratrol intake for 12 weeks improves insulin sensitivity by lowering the
Homeostasis model assessment of insulin resistance (HOMA-IR), an index of insulin resistance
and, that resveratrol intake will cause an increase in incretins.