Resveratrol is derived from plants and is found in highest levels in red wine and the skin of
red grapes. A recent study reported that monthly and weekly consumption of red wine is
associated with a lower risk of dementia. There is compelling evidence that caloric
restriction can improve overall health by activating a class of enzymes known as Sirtuins.
Resveratrol is a substance found in some plants that directly activates sirtuins, mimicking
the effects of caloric restriction and may affect regulatory pathways of diseases of aging,
including Alzheimer's disease (AD).
In this study, people with AD will be given either Resveratrol or placebo for 12 months to
determine whether daily resveratrol therapy is beneficial in delaying or altering the
deterioration of memory and daily functioning. Subjects age 50 and above with a diagnosis of
probable AD may qualify for participation in this study. A small group of 15 participants
will be asked to take part in a more detailed 24-hour Pharmacokinetic (PK) sub-study that
will measure resveratrol levels over a 24 hour period.