Resveratrol and Cardiovascular Health in the Elderly
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
Background:
- Resveratrol is a compound found in the skin of red grapes. It is being tested to see if it
can have positive effects on human health. Lab studies show that it may help lower blood
sugar, improve heart and blood vessel health, and prevent cancer. Researchers want to test
different dose levels of Resveratrol to see what kind of effects it has on older overweight
people. It will be tested in healthy volunteers at least 50 years of age.
Objectives:
- To test the effects of different dose levels of Resveratrol on heart and blood vessel
health.
Eligibility:
- Healthy overweight nonsmoking volunteers at least 50 years of age.
Design:
- This study will involve a screening visit and four study visits. Some of the study
visits will involve overnight inpatient stays.
- Participants will be screened with a physical exam and medical history. Blood and urine
samples will be collected. They will be given a list of foods that they should avoid
eating while on the study.
- Participants will be separated into three groups. Two groups will take different dose
levels of the study drug. The third group will take a placebo.
- At the first study visit, participants will stay in the clinical center overnight for 2
days of tests. They will provide blood and urine samples and have body scans to measure
fat and muscle mass. They will also have exercise tests. A muscle biopsy will also be
performed. At this visit, they will receive their dose of the study drug. They will
continue to take this dose for as long as they are on the study.
- The second visit will be 16 weeks after the first one. It will take only 2 hours, and
repeat most of the tests from the screening visit.
- The third visit will be 16 weeks later. It will involve an overnight stay. Most of the
tests from the second visit will be repeated.
- The fourth and final visit will be 16 weeks later. It will involve an overnight stay.
Most of the tests from the initial study visit (including the scans and the exercise
tests) will be repeated.