Restoration of Retinal Vascular Responses in Type 1 Diabetic Patients
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
Diabetic retinopathy is the leading cause of blindness in the developed world. The causes of
the disease are poorly understood. One of the earliest changes that occur in the retinas of
diabetic patients, well before overt retinopathy is observed, is a reduction in light-evoked
increases in blood flow in retinal vessels. The loss of this vascular response may lead to
retinal hypoxia and it has been suggested that hypoxia could be a principal cause of diabetic
retinopathy.
The long-term goals of this project are to determine whether decreased blood flow in diabetic
patients and the resulting retinal hypoxia contributes to the development of diabetic
retinopathy and whether restoration of normal blood flow in diabetic patients slows or
prevents the development of retinopathy.
Phase:
Phase 1
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute