Responses of Myocardial Ischemia to Escitalopram Treatment
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
Depression is commonly seen in patients with cardiovascular disorders. In recent studies it
has been shown that mild to moderate depression symptoms were associated with increased
likelihood of mental stress-induced myocardial ischemia (MSIMI), which is a risk factor of
poor cardiac outcome. In this project, the investigators aim to assess the treatment of
mental stress-induced myocardial ischemia in ischemic heart disease patients with mild to
moderate depressive symptoms. This study is a six-week double-blind placebo controlled study
to examine the effects of escitalopram on mental stress-induced myocardial ischemia. This
study will look to show that patients with ischemic heart disease who are treated with
escitalopram will exhibit a significant improvement of MSIMI at the end of week 6 compared to
patients receiving placebo.