This research is to investigate the response of vascular active factors, vascular endothelial
growth factor (VEGF) and angiotensin-Ⅱ (AT-Ⅱ) to ovary stimulation during 24h in patients
with polycystic ovary syndrome (PCOS).Controled prospective clinical study involved 60 women
undergoing in vitro fertilization. Fifty-two patients with PCOS and 8 control cases were
stimulated with human chorionic gonadotropin (HCG) during the early follicular phase of the
menstrual cycle (4st to 7th days of the cycle).The blood was sampled before the injection (0
hour) and at the 3, 6, 12, 18 and 24 hours points after the stimulation. VEGF, AT-Ⅱ were
measured by radioimmunoassay.
Phase:
Early Phase 1
Details
Lead Sponsor:
Nanjing University School of Medicine
Treatments:
Angiotensin II Angiotensinogen Chorionic Gonadotropin Endothelial Growth Factors