Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme

• Status: Not yet recruiting
• Trial end date: 2023-05-22
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose the use of a 20 week physician-derived exercise programme will lead to an improvement in physical fitness which will in turn lead to an increase in muscle mass, a reduction in visceral obesity resulting in an improvement in biologic response, disease biomarkers (including a reduction in circulating pro-inflammatory cytokines), fatigue scores and quality of life.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Royal College of Surgeons, Ireland

Criteria

Inclusion Criteria:

• 18 years of age or above.

• Confirmed moderate to severe inflammatory bowel disease based on endoscopic evaluation, clinical scoring tools and faecal calprotectin.

• Be able to provide written informed consent.

• Stable dose of steroids.

• Physically able to complete an exercise programme.

• Healthy controls.

Exclusion Criteria:

• Inability to participate in the exercise program (unable to perform 6MWT, unable to attend for assessment of parameters at any time point).

• An uncontrolled cardiovascular condition such as unstable angina, uncontrolled cardiac arrhythmias, uncontrolled symptomatic heart failure or symptomatic severe aortic stenosis.

• A significant musculoskeletal condition, neurological condition, mental illness or intellectual disability that restricts participation in a physical exercise program.

• Pregnancy.

• Healthy controls with underlying inflammatory conditions.