Residual Platelet Activity In Advanced Peripheral Artery Disease

• Status: Unknown status
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The peripheral arterial disease (PAD) is a common atherosclerotic disease manifestation and its prevalence increase with age and with the simultaneous presence of cardiovascular risk factors.

PAD patients are usually treated, as a first line treatment, with the exercise therapy, combined with the pharmacological antiplatelet therapy.

In the case of first line therapy failure, PAD patients usually undergoing to invasive revascularization procedures.

After a peripheral stent has been located, the major follow-up problem is the restenosis rate.

Published studies describe how, in a large amount of patients, can be recognised an high residual platelet activity. These data about PAD patients at the moment are lacking .

The authors would evaluate the incidence of PAD patients with an high residual platelet activity.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Roma La Sapienza
• Collaborator: University of Florence
• Treatments: Aspirin; Clopidogrel

Criteria

Inclusion Criteria:

• Claudicatio Intermittens affected patients in which both exercise than pharmacological therapies failed

• Ankle Brachial Index < 0.9 or > 1.3

• Peripheral Arteries stenosis > 50% bilateral

Exclusion Criteria:

• Acute Limb Ischemia patients

• Patients that underwent a peripheral revascularization procedure within 6 months