Research on Individualized Treatment for Alcoholism

• Status: Completed
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study was to compare the effects of two psychosocial treatments that differed in scope and intensity (Broad Spectrum Treatment and Motivational Enhancement Treatment) combined with 3 or 6 months of treatment with naltrexone on alcohol drinking behaviors in alcohol dependent patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Indiana University School of Medicine
• Collaborators: Brown University; George Washington University; VA Boston Healthcare System
• Treatments: Naltrexone

Criteria

Inclusion Criteria:

• men and women between the ages of 21-65

• current DSM-IV diagnosis of alcohol dependence

• abstinent for a minimum of 3 and maximum of 21 days prior to treatment initiation

• able to participate in an 18-month outpatient study

• live within a one hour or less commute to Fairbanks

• fluent in English

• women of child-bearing potential must have a negative pregnancy test and use effective contraceptive methods.

• score as contemplators or greater on the Readiness For Change Scale

Exclusion Criteria:

• severe hepatic disease (gGGT, SGOT or other liver functions greater than 4 times normal)

• opiate use (for any reason) in the last 14 days or a history of opioid dependence in the past year

• pregnant or lactating females or those unwilling to use birth control

• inability, according to the opinion of the interviewer, to follow medication instructions and safety precautions

• comorbid substance dependence (but not abuse) diagnosis in the past 6 months, excluding nicotine or marijuana dependence

• concomitant use of medications intended to decrease drinking (e.g. disulfiram)

• meeting current DSM criteria for bipolar disorder, schizophrenia, bulimia/anorexia, dementia, major depression