Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis
Status:
Recruiting
Trial end date:
2023-06-12
Target enrollment:
Participant gender:
Summary
This study will look at participants body weight from the start to the end of the study. It
will also look at how much pain participants have in participants knee from the start to the
end of the study and how this affects participants daily life. This is to compare the effect
on body weight and pain in the knee in people taking semaglutide with people taking "dummy"
medicine. Participants will either get semaglutide or "dummy" medicine. Which treatment
participants get is decided by chance.
Participants will need to take 1 injection once a week. The study medicine is injected with a
thin needle in a skin fold in the stomach, thigh or upper arm. During the study, participants
will have talks with study staff about how to eat healthy food and how to be more physically
active. The study will last for about 1 ½ years. Participants will have 14 clinic visits with
the study staff. At the first clinic visit participants will have a blood sample taken.
Participants will have an X-ray of participants knee taken at the first visit. If
participants have had an X-ray recently, this may not be needed.
At 6 of the clinic visits participants cannot take pain medications for 3 days before the
visit. Participants cannot take part if participants have had a joint replacement surgery in
participants knee. Participants cannot take part if participants have or have had diabetes.
Women: Women cannot take part if pregnant, breast-feeding or plan to become pregnant during
the study period.