Overview Research Investigation of Soy and Estrogen Status: Completed Trial end date: 2015-05-01 Target enrollment: Participant gender: Summary The purpose of this study is to determine the effects of oral estradiol and soy phytoestrogens on anxiety, stress responsivity and cognition in perimenopausal women. Phase: Phase 2 Details Lead Sponsor: University of Illinois at ChicagoCollaborator: National Institute of Mental Health (NIMH)Treatments: EstradiolEstradiol 17 beta-cypionateEstradiol 3-benzoateEstradiol valerateEstrogensMedroxyprogesteroneMedroxyprogesterone AcetatePhytoestrogensPolyestradiol phosphate