Rescue Regimen and High Dose Methotrexate in Management of Presistent Gestational Trophoplastic Neoplasia
Status:
Unknown status
Trial end date:
2019-10-01
Target enrollment:
Participant gender:
Summary
Gestational trophoblastic neoplasia (GTN) are malignant lesions that arise from abnormal
proliferation of placental trophoblast. The pathologic conditions that make up this entity
include invasive partial and complete hydatidiform mole, choriocarcinoma, placental site
trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). GTN often arises after
molar pregnancies but can also occur after any gestation including miscarriages and term
pregnancies. In the United States, hydatidiform moles are observed in approximately 1/600
therapeutic abortions and 1/1000-2000 pregnancies . Most cases of GTN are diagnosed when the
serum hCG levels plateau or rise in patients being observed after the diagnosis of
hydatidiform mole.These malignancies are highly susceptible to chemotherapy and it is often
possible to achieve cure while preserving the woman's reproductive function