Replacement of Nebulised Ipratropium With Inhaled Tiotropium in Stable Chronic Obstructive Pulmonary Disease (COPD)
Status:
Withdrawn
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Some patients with chronic obstructive pulmonary disease (COPD) take nebulised treatments to
ease the symptom of breathlessness, including the drug ipratropium. Nebulised bronchodilator
drugs are taken up to 4 times through the day, and this can take up to 15 minutes each time.
Although the treatment isbe effective, patients report that the time taken to set-up and use
the nebuliser can be a disincentive to regular use. By contrast, an inhaler device is easy to
use following appropriate instruction, and takes only a few seconds to administer. Inhaled
tiotropium is a once daily treatment taken by inhaler which has been shown to be effective in
COPD. We wish to assess whether inhaled Tiotropium as effective as nebulised ipratropium in
patients with stable chronic obstructive pulmonary disease.