Renin Profiling in Selection of Initial Antihypertensive Drug

• Status: Completed
• Trial end date: 2011-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to determine whether a simple blood test measuring a hormone called renin can better determine which first drug would be most effective in controlling blood pressure, in comparison with the more traditional approach recommended by JNC7 (Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Louis & Rachel Rudin Foundation
• Collaborators: Daiichi Sankyo Inc.; Daiichi Sankyo, Inc.
• Treatments: Amlodipine; Antihypertensive Agents; Hydrochlorothiazide; Olmesartan; Olmesartan Medoxomil

Criteria

Inclusion Criteria:

• Males and females, 40 to 85 years of age

• Sustained systolic blood pressure between 140-180 mm Hg

• Free of antihypertensive therapy at randomization for at least 4 weeks

Exclusion criteria:

• Ages <40, or >85 years

• Systolic blood pressure >180 mm Hg

• Blood pressure >180/105 mm Hg during the washout period

• Require antihypertensive agents for non-blood pressure indications

• Taking clonidine

• On a beta-blocker drug and have known or suspected coronary artery disease

• Documented history of a heart attack, new onset of chest pain, or a coronary revascularization procedure within the past year, congestive heart failure

• Serious intercurrent illness

• An active ulcer

• Have certain abnormal laboratory tests (elevated serum creatinine >1.5 mg/dl, transaminase > 2 times upper limit of normal or active liver disease),

• Hypersensitivity, allergy or have an intolerance to angiotensin II receptor blockers (olmesartan), hydrochlorothiazide or amlodipine

• Mentally or legally unable to participate

• Have or are currently abusing alcohol, have abused drugs within the past 2 years

• Have been in another drug study in the past month.