Renal Oxygenation, Oxygen Consumption and Hemodynamic Kinetics in Type 2 DIabetes: an Ertugliflozin Study.
Status:
Recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
Current study will render insight in to the role of renal hypoxia in the diabetic kidney and
is able to associate its finding with measurements of renal perfusion and glomerular
filtration rate. Moreover, this research will focus on the effects of sodium-glucose
cotransporter 2 inhibition on renal tissue oxygenation and oxygen consumption as well as a
change in intrarenal hemodynamics and perfusion, and a shift of fuel metabolites. Elucidation
the mechanisms underlying the effects of SGLT2 inhibition will advance our knowledge and
contribute to their optimal clinical utilization in the treatment of chronic kidney disease
in diabetes and possibly beyond.