Remifentanil and Laryngeal Reflex Responses in Pediatric Patients With URI
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
To describe respiratory and laryngeal responses to laryngeal stimulation during propofol
anesthesia in children with upper airway infections. To determine whether the
co-administration of remifentanil blunts these reflex responses. To test whether the
co-administration of remifentanil results in a significant reduction of apnea with
laryngospasm in these patients.
Hypotheses:
I: In children with a URI undergoing anesthesia with propofol, the incidence of apnea and
laryngospasm after controlled stimulation is expected to occur 2.5 times more frequently than
in children without URI (20 vs. 8%).
II: The incidence of apnea and laryngospasm is diminished after administration of
remifentanil.