Remifentanil and Laryngeal Reflex Responses in Pediatric Patients With URI

• Status: Completed
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

To describe respiratory and laryngeal responses to laryngeal stimulation during propofol anesthesia in children with upper airway infections. To determine whether the co-administration of remifentanil blunts these reflex responses. To test whether the co-administration of remifentanil results in a significant reduction of apnea with laryngospasm in these patients.

Hypotheses:

I: In children with a URI undergoing anesthesia with propofol, the incidence of apnea and laryngospasm after controlled stimulation is expected to occur 2.5 times more frequently than in children without URI (20 vs. 8%).

II: The incidence of apnea and laryngospasm is diminished after administration of remifentanil.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Thomas Erb
• Treatments: Propofol; Remifentanil

Criteria

Inclusion Criteria:

• ASA I + II

• elective intervention under general anesthesia

• acute upper respiratory tract infection

Exclusion Criteria:

• chronic respiratory tract infection

• fever >38,3° celsius

• productive cough

• neuromuscular disease

• malignant hyperthermia

• cardiac disease