Remifentanil Without Muscle Relaxant for Thoracotomy
Status:
Completed
Trial end date:
2014-03-01
Target enrollment:
Participant gender:
Summary
Although the administration of muscle relaxation is essential standard of care for thoracic
procedures, it could cause long-reversal times and postoperative residual curarization (PORC)
increasing length of post-anesthesia care unit (PACU) stay and hospital costs. Sugammadex
offers new perspectives to reduce the incidence of PORC. Unfortunately it is not available in
many countries because of its significantly high cost. We hypothesized that the use of
target-controlled remifentanil infusion (TCI) with the non-muscle relaxant (NMR) would be
associated with comparable surgical conditions and reduced total costs compared with the use
of neuromuscular blockers during thoracotomy.
After ethical approval, 66 patients scheduled for elective thoracotomy under sevoflurane
anesthesia with TCI remifentanil will be included in this prospective, randomized,
single-blind, controlled study.
Patients will be randomly assigned to receive cisatracurium or saline (n = 33 for each group)
throughout the procedure. Laryngoscopy and intubating conditions, intraoperative modified
thoracic surgery rating scale (Table below), incidence of light anesthesia, and use of
vasopressors and anesthetics, clinical recovery, incidence of PORC, PACU and hospital stays,
and total costs will be recorded.