Overview

Remifentanil Use in Pediatric Rigid Bronchoscopy

Status:
Completed
Trial end date:
2006-08-01
Target enrollment:
0
Participant gender:
All
Summary
Purpose: In this study we wanted to compare bolus propofol and ketamine as an adjuvant to remifentanil-based total intravenous anesthesia for pediatric rigid bronchoscopy. Materials and Methods: Forty children under 12 years of age scheduled for rigid bronchoscopy were included. After midazolam premedication, remifentanil infusion 1 µg/kg/min was started and patients were randomly allocated to receive either propofol (Group P) or ketamine (Group K) and mivacurium for muscle relaxation. Anesthesia was maintained with remifentanil infusion 1 µg/kg/min and bolus doses of propofol or ketamine. After rigid bronchoscopy remifentanil 0.05 µg/kg/min was maintained until extubation. Hemodynamic parameters, emergence characteristics and adverse events were evaluated.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Bezmialem Vakif University
Treatments:
Ketamine
Propofol
Remifentanil
Criteria
Inclusion Criteria:

- Children who were scheduled to have rigid bronchoscopy for diagnostic purposes
(suspected foreign body aspiration, bronchoalveolar lavage)

- Children who were scheduled to have rigid bronchoscopy for therapeutic purposes
(removal of foreign bodies and/or mucus plugs)

Exclusion Criteria:

- Severe cardiovascular disease

- Cerebral, hepatic or renal dysfunction

- Neuromuscular disease

- Children with predicted difficulty in laryngoscopy and intubation

- Patients requiring prompt interventions for a life-threatening situation (acutely
compromised airway with SpO2 values below 70%)

- Patients scheduled for additional interventions or surgery subsequent to rigid
bronchoscopy