Remifentanil Anesthesia and Postoperative BIS in Cardiac Surgery
Status:
Completed
Trial end date:
2016-10-01
Target enrollment:
Participant gender:
Summary
Background: Although remifentanil based anesthesia has been preferred for fast-track cardiac
anesthesia, its recovery profile in cognitive function has not been investigated. Authors
determined postoperative Bispectral index (BIS) score as well as extubation time after
remifentanil-based propofol-supplemented anesthesia and compared them with those after
conventional balanced sevoflurane-sufentanil anesthesia.
Methods: Patients undergoing cardiac surgery using moderate hypothermic cardiopulmonary
bypass (CPB) will be randomly allocated to get remifentanil-based propofol-supplemented
(Group R) or conventional sevoflurane-sufentanil regimen (Group C) in the study period. For
anesthetic induction and maintenance, fixed target controlled infusion (TCI) of remifentanil
(plasma concentration 20 ng/ml) and TCI-propofol for maintaining BIS score 40-60 (effect
concentration 0.8-1.5 μg/ml) in Group R, and TCI-sufentanil (Cp 0.4- 0.8 ng/ml) and
sevoflurane inhalation for maintaining 80-120 % of baseline BP and BIS < 60 (< 1.5 MAC) in
Group C, respectively.
Authors will analyze postoperative recovery of cognitive function by using BIS after the use
of remifentanil-based propofol-supplemented anesthesia for cardiac surgery and to compare
them to those after the use of conventional balanced sevoflurane-sufentanil anesthesia.